Induced Pluripotent Stem Cell

Induced Pluripotent Stem Cell Since 2019, SCI initiated research in developing induced Pluripotent Stem Cells (iPSCs) generated by reprogramming adult cells or more specialized cells and reversing their state back to pluripotent which is the stage when cells still have their ability to differentiate into various cell types in the body. SCI tried several methods of reprogramming using the footprint-free protocol to assess its possibility for application in regenerative therapy. This technology is accomplished by introducing a specific combination of genes into the mature or more specialized cells. The genes used in the reprogramming protocol are typically known as "reprogramming factors," with the most common combination being Oct4, Sox2, Klf4, and c-Myc (known as the OSKM factors). The resulting cells share many characteristics with embryonic stem cells, including their potency to self-renew and differentiate into several different cell types. They can give rise to cells from all three germ layers: endoderm, mesoderm, and ectoderm, which can develop into various specialized cells, such as neurons, muscle, adipose, osteo, and many more.